Rosacea
ICD-10 L71.9 · ICD-11 ED90.0

Rosacea with Reddish-Brown Facial Papules or Nodules and Diffuse Facial Erythema

This protocol addresses the granulomatous subtype of rosacea — also known as lupoid rosacea — which presents with reddish-brown papules or nodules occurring alongside diffuse facial erythema and is confirmed histologically.

Reddish-brown papules or nodules presenting concomitantly with diffuse facial erythema are the hallmark sign for granulomatous rosacea. In this subtype, histological examination reveals non-caseating epithelioid cell granulomas, distinguishing it from other rosacea presentations.

Treatment Overview

Management of granulomatous rosacea draws on both systemic and procedural options, alongside topical agents that have demonstrated effectiveness in this presentation. The structured regimen — including the sequencing of therapeutic options — is available in full via the protocol below.

Instant Access to Structured Evidence-Based Regimens

References

DOI: 10.1111/jdv.14349

Reddish-brown papules or nodules presenting concomitantly with diffuse facial erythema are the hallmark sign for granulomatous rosacea also known as lupoid rosacea.

In the granulomatous subtype of rosacea, non-caseating epithelioid cell granulomas arise.

Minocycline, dapsone, isotretinoin and intense pulsed light (IPL) have been published as successful treatments.

Topical treatments with pimecrolimus cream and azelaic acid gel were successful.

In practice, treatment that has qualified for papulopustular rosacea can be used for GR.

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