Treatment of Rickets in Dietary Phosphate Deficiency and Impaired Dietary Phosphate Availability (Phosphopenic Rickets)
This protocol covers phosphopenic rickets driven by dietary phosphate deficiency or impaired dietary phosphate availability — including infants on amino acid-based elemental formulas and patients with conditions that limit phosphate absorption from the gastrointestinal tract.
Management centres on correcting the phosphate deficit through phosphate supplementation or dietary modification, with the specific form and route of intervention determined by the underlying cause.
References
DOI: 10.1007/s00467-022-05505-5
Adequate dietary or additional oral phosphate supplementation will correct dietary phosphate deficiency, whereas in case of impaired dietary phosphate availability, such as in infants on amino acid-based elemental formulas (e.g., Neocate), a change of formula will cure rickets.
Management of impaired phosphate absorption, e.g., due to gastrointestinal surgery or short bowel syndrome, are treated with oral or if necessary parenteral phosphate supplementation.
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