Treatment of Rickets in Autosomal-Recessive Hypophosphatemic Rickets Type 1 (DMP1 Gene Mutation)

This protocol applies to patients with rickets arising from autosomal-recessive hypophosphatemic rickets type 1 (ARHR1), a rare hereditary disorder caused by loss-of-function mutations in the DMP1 gene (dentin matrix protein 1).

The management strategy involves a combination of phosphate supplementation and an active vitamin D analog — the specific agents, sequencing, and monitoring parameters are defined in the full structured protocol.