This protocol covers rhino-orbital-cerebral mucormycosis in the specific setting where infection has extended to involve the central nervous system, including brain parenchyma — a severe disease extension that demands immediate, structured clinical action.
The approach centres on early and complete surgical intervention combined with prompt, high-intensity systemic antifungal therapy. Surgical debridement and antifungal treatment are initiated together; once a response is established, the regimen may be adjusted. The full protocol — including specific agents, sequence, and criteria for transitioning to oral therapy — is available via the link below.
The primary objective is stable disease or partial response of mucormycosis on response assessment, such as weekly imaging.