Treatment of Renal Cell Carcinoma — Organ-Confined T1 Tumour Measuring ≤7 cm
This protocol addresses renal cell carcinoma presenting as an organ-confined T1 tumour measuring ≤7 cm — a stage at which treatment strategy depends on surgical feasibility and individual patient characteristics.
Clinical scenario: Organ-confined renal cell carcinoma with a T1 tumour ≤7 cm. This is considered an elective indication where nephron-sparing is the primary surgical objective.
Treatment overview: Surgical resection with nephron preservation is the preferred approach where technically feasible; alternative management strategies exist for patients in whom this is not appropriate. The complete structured protocol specifies the options and selection criteria.
References
DOI: 10.1016/j.annonc.2024.05.537
- Partial nephrectomy (PN) is the preferred option in organ-confined tumours measuring 7 cm (elective indication).
- PN can be carried out via open, laparoscopic or robot-assisted laparoscopic approaches.
- Conventional or robot-assisted laparoscopic RN is recommended if PN is not technically feasible.
- Radiofrequency ablation (RFA), stereotactic body radiotherapy (SBRT), microwave ablation and cryoablation (CA) are non-surgical options, particularly in patients with small cortical tumours.
- These may be especially appropriate for patients who are frail, present a high surgical risk, have a solitary kidney, compromised renal function, hereditary RCC or multiple bilateral tumours, or decline surgery.
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