Treatment of Locally Advanced, Unresectable Renal Cell Carcinoma or Patients Unfit for Surgery
This protocol addresses the management of renal cell carcinoma (RCC) that has progressed to a locally advanced stage where surgical resection is not feasible — either because the disease is unresectable, or because the patient is not a surgical candidate.
Clinical Scenario
Locally advanced renal cell carcinoma that is unresectable and/or where the patient is unfit for surgery. In this setting, the multidisciplinary team must weigh systemic, interventional, and palliative options — including the possibility of deferred resection — to determine an individualised treatment goal.
Treatment Approach (Partial Overview)
Management centres on individualised systemic therapy coordinated within a multidisciplinary team. For patients with unresectable disease, interventional approaches may be considered to control symptoms such as visible haematuria or flank pain. The full evidence-based regimen — including sequencing, palliative options, and decision criteria — is available via the structured protocol.
References
- Patients unfit for surgery and/or with unresectable RCC
- The management of locally advanced unresectable RCC should be based around systemic therapy.
- In patients with unresectable disease, embolisation can control symptoms, including visible haematuria or flank pain.
- Discuss treatment options in patients with locally advanced unresectable RCC (biopsy and/or systemic therapy/deferred resection or palliative management) within a multidisciplinary team to determine treatment goal.
View source ↗