Recurrent respiratory papillomatosis requires repeated operative management, and in patients with significant disease burden the approach goes beyond ablation alone. A combined surgical and adjuvant strategy is indicated for patients who carry a heavier clinical burden.

This protocol applies to patients with moderate to severe RRP: those who require frequent surgery, have worsening airway compromise, suffer severely impaired communication, or who might otherwise be considered candidates for tracheostomy.

Treatment approach

The protocol combines conventional surgical ablation with intralesional injection of an adjuvant agent delivered directly at the base of removed lesions. The complete regimen — including candidacy criteria, technique details, and needle selection — is contained in the full structured protocol.

References

DOI: 10.5005/jp-journals-10023-1008

Cidofovir should be routinely presented as a treatment option in moderately to severely afflicted RRP patients; that is, those patients who require frequent surgery, have worsening airway compromise or severely impaired communication or who may otherwise be considered for tracheostomy.
It is done by ablation of the papillomas, a Storz needle is used to inject cidofovir at the base of the removed lesion.
An alternative disposable needle is a 22 gauge 7.00 in spinal needle.

View source ↗

What is the treatment of Recurrent Respiratory Papillomatosis in moderately to severely afflicted patients?

Treatment approach

References