This protocol addresses rectal cancer arising within a sessile adenoma of the rectum where the cancer is confined to the submucosa (pT1) and the lesion was removed as a single specimen with clear surgical margins and favorable histologic characteristics.
The pathologic findings define a well-circumscribed situation: a sessile rectal polyp with focal invasive cancer (pT1), excised as a single specimen and completely removed. Favorable histology — including low-grade differentiation, negative margins, and no lymphovascular invasion — characterises this sub-population. Both endoscopic polypectomy and rectal surgery are recognised management options in this setting.
Management is guided by the pathologic stage. Adjuvant treatment may be considered based on the findings, with a perioperative window of up to approximately six months. Full regimen details, sequencing, and individualised recommendations are available in the complete protocol.