This protocol addresses pediatric patients aged 1 month to less than 18 years presenting with systemic anthrax from inhalation (pulmonary) exposure, with or without concurrent meningitis.
Empiric management in this age group involves a structured combination regimen — multiple antimicrobial agents paired with antitoxin as adjunctive therapy. The full drug selection criteria, class combinations, and transition guidance are available in the complete protocol.
Empiric treatment regimens for children aged >1 month to <18 years with systemic anthrax with or without meningitis (Table 14) are summarized as follows:
Antimicrobial drugs: Choose two bactericidal drugs from different antimicrobial drug classes plus a PSI or an RNAI.
Antitoxin: Choose a single antitoxin as adjunctive therapy.
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