Tratamento da Encefalite Viral na Encefalite pelo Vírus B
A encefalite viral no contexto da infecção pelo vírus B é um cenário clínico distinto e grave. O envolvimento do sistema nervoso central é um fator-chave que influencia diretamente a seleção do agente e a duração do tratamento.
DOI: 10.1086/589747
B virus: valacyclovir is recommended (B-III); alternative agents are ganciclovir (B-III) and acyclovir (C-III).
Valacyclovir (1 g orally every 8 h) is recommended because higher serum concentrations can be achieved.
Some experts recommend ganciclovir (5 mg/kg intravenously every 12 h for a minimum of 14 days or until all CNS symptoms have resolved) if the CNS is involved; subsequent administration of valacyclovir for suppression of latent infection may also be considered.
Acyclovir (12.5–15 mg/kg intravenously every 8 h) has been suggested for acute infection; case reports in patients with B virus encephalitis have demonstrated full recovery, although the efficacy of this approach has not been systematically examined.
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