Em pacientes com Demência com Corpos de Lewy (DLB), o declínio cognitivo e o comprometimento cognitivo estão entre as manifestações clinicamente mais significativas. O manejo desses sintomas requer uma abordagem focada e baseada em evidências, que vise a cognição, a função global e a capacidade para as atividades cotidianas.
DOI: 10.1212/WNL.0000000000004058
Treatment of DLB is focused on the cognitive, psychiatric, motor, and other nonmotor symptoms that represent the core or most common features of the disorder.
Meta-analyses of Class I clinical trials of rivastigmine and donepezil support the use of cholinesterase inhibitors (CHEIs) in DLB for improving cognition, global function, and activities of living, with evidence that even if patients do not improve with CHEIs they are less likely to deteriorate while taking them.
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