Este protocolo destina-se a doentes com pancreatite crónica no estádio compensado — uma fase em que a função pancreática permanece em grande parte preservada, mas a dor abdominal e a dor dorsal dominam o quadro clínico e orientam as prioridades de tratamento.
O regime de primeira linha baseado em evidências centra-se na terapêutica analgésica como abordagem inicial tanto para a dor abdominal como para a dor dorsal, acompanhada de uma modificação dietética estruturada a curto prazo. O regime completo — incluindo medidas farmacológicas adicionais e o algoritmo clínico integral — está disponível no protocolo.
Abdominal pain is the main symptom during the latent to compensatory stage, when there is no obvious impairment of pancreatic endocrine and exocrine function.
In the compensated stage, prevention of repeated relapses and pain takes priority.
Nonsteroidal anti-inflammatory drugs (NSAIDs) are the first choice for analgesia, and if inadequate, weak opioids are useful for both abdominal pain and back pain.
A short-term low-fat diet (fat 30–35 g/day; fat ≤ 10 g/meal) is recommended for patients with compensatory abdominal pain and back pain.
We propose use of a proteolytic enzyme inhibitor as a treatment for pain.
A combination of camostat mesilate, pancrelipase, and rabeprazole has been reported to achieve significant improvement in epigastric pain in patients with early stage CP.
DOI: 10.1007/s00535-022-01911-6 View source ↗