Treatment of Psoriasis with Concomitant Uveitis (Inflammation of the Uveal Tract of the Eye)

Psoriasis can present alongside ocular involvement, most notably uveitis — inflammation of the uveal tract of the eye. This co-occurrence requires a management approach that addresses both the skin disease and the active ocular inflammation simultaneously.

Clinical Scenario

Patient has psoriasis with concurrent uveitis (inflammation of the uveal tract). Anterior uveal involvement (iritis) can be seen in psoriasis patients, and is particularly associated with those who also have psoriatic arthritis (PsA). The presence of active uveitis shapes the treatment selection.

Treatment Approach (Partial Overview)

The protocol involves a targeted biologic agent with established evidence for managing both psoriasis and concomitant uveitis — the full regimen, agent selection criteria, and supporting evidence are available in the complete protocol.

Treatment Goal

Remission of uveitis.

Instant Access to Structured Evidence-Based Regimens

References

DOI: 10.1016/j.jaad.2018.11.058

Involvement of the anterior portion of the uveal tract (iritis) can be seen in patients with psoriasis, especially those with PsA.

With regards to management of psoriasis with concomitant uveitis, a case series of 8 patients with both psoriasis and uveitis were treated with either infliximab (n = 4) or adalimumab (n = 4).

Of those patients, 7 achieved remission of their uveitis.

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