Psoriasis during pregnancy presents a distinct clinical challenge. Achieving adequate disease control must be weighed carefully against the safety of any intervention for the developing fetus.

Clinical Scenario

This protocol applies to pregnant patients with generalized plaque psoriasis or chronic guttate psoriasis. Pregnancy substantially narrows the range of appropriate therapies and shapes both the choice of treatment and any adjunctive measures used alongside it.

Treatment Approach

NB-UVB phototherapy — considered safe in pregnancy — is the recommended intervention, used alongside oral folate supplementation to reduce fetal risk. The complete regimen, including dosing, sequencing, and monitoring parameters, is available in the structured protocol.

References

NB-UVB phototherapy is recommended for pregnant women with generalized plaque psoriasis and guttate psoriasis.
NB-UVB is considered safe in pregnancy and is recommended for the treatment of generalized plaque or chronic guttate psoriasis.
All women of childbearing potential who are being treated with phototherapy should supplement with folate to decrease the risk of neural tube defects resulting from unplanned pregnancies.
Women of childbearing age receiving NB-UVB phototherapy should take folate supplementation.

DOI: 10.1016/j.jaad.2019.04.042

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Treatment of Psoriasis in Pregnancy: Generalized Plaque Psoriasis or Chronic Guttate Psoriasis

References