What Is the Treatment of Psoriasis on the Palms and Soles (Palmoplantar Psoriasis)?

Clinical Scenario

Palmoplantar psoriasis refers to psoriatic involvement localised to the palms of the hands and the soles of the feet. This anatomical distribution poses distinct therapeutic challenges, as skin in these areas is thicker and subject to constant mechanical stress.

Treatment Approach

Management involves topical corticosteroid therapy — specifically at an ultrahigh-potency level — applied over longer durations than are typical for psoriasis at other body sites. Close monitoring for potential adverse effects is an integral part of the approach.

The complete protocol — including selection criteria, duration guidance, monitoring parameters, and sequencing — is available via the link below.

Instant Access to Structured Evidence-Based Regimens

References

DOI: 10.1016/j.jaad.2020.07.087

Longer durations of class 1 corticosteroid therapy for psoriasis of the palms and soles are acceptable with close attention to the development of potential adverse effects.

Topical maxcalcitol (not available in the US) ointment can be considered as an initial treatment for palmoplantar psoriasis, including palmoplantar pustulosis.

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