Treatment of Protein C Deficiency with Family History of Venous Thromboembolism

This protocol applies to patients with known Protein C deficiency who also have a family history of venous thromboembolism and are currently exposed to a minor provoking risk factor for VTE.

The minor provoking risk factors in this scenario include transient immobility, minor injury, intercurrent illness, or infection — short-lived exposures that elevate VTE risk in this high-risk thrombophilia population.

Because family history of VTE is present alongside a confirmed high-risk thrombophilia, testing for the known familial thrombophilia is also a relevant consideration in this clinical context.

The approach in this setting involves thromboprophylaxis timed to the period of elevated risk — the complete structured regimen is available via the protocol below.