Protein C deficiency
ICD-10 D68.5 · ICD-11 3B61.0Y.1

Protein C Deficiency in Women with a Family History of Venous Thromboembolism Considering Hormone Replacement Therapy

Women with Protein C deficiency who also have a family history of venous thromboembolism (VTE) face elevated thrombotic risk. When such a patient is considering hormone replacement therapy (HRT), this specific combination warrants a structured, evidence-based approach.

This protocol applies to a female patient with Protein C deficiency and a family history of venous thromboembolism — a high-risk thrombophilia profile — who is evaluating whether to start hormone replacement therapy. The ASH guideline panel recommends that women in this situation be tested for the known familial thrombophilia before any decision is made regarding HRT.

Treatment approach (partial summary)

The recommended approach centres on a specific management decision regarding hormone replacement therapy for women with this high-risk thrombophilia profile. The full structured regimen — including the complete algorithm and all clinical considerations — is available via the protocol below.

Instant Access to Structured Evidence-Based Regimens

References

For women with a family history of VTE and known antithrombin, protein C, or protein S deficiency in the family (high-risk thrombophilia), the ASH guideline panel suggests testing for the known familial thrombophilia.

The panel suggests avoidance of HRT for women with high-risk thrombophilia.

DOI: 10.1111/jth.15732

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