Primary sclerosing cholangitis
ICD-10 K83.0 · ICD-11 DB96.2

PSC with Pruritus and Dominant or Relevant Biliary Stricture

In patients with Primary sclerosing cholangitis, the new onset or worsening of pruritus (skin itching) can signal an underlying biliary complication requiring prompt evaluation and intervention.

Clinical Scenario

This protocol addresses PSC patients presenting with:

New or worsening itch in a PSC patient may indicate benign or malignant biliary obstruction. A relevant biliary stricture should be ruled out before attributing pruritus to other causes.

Management Approach

When a relevant biliary stricture is identified, management involves an endoscopic biliary intervention — the full structured protocol specifies the procedural approach, sequencing, and clinical decision points.

Instant Access to Structured Evidence-Based Regimens

References

DOI: 10.1002/hep.32771

In a patient with PSC and new-onset pruritus, a relevant biliary stricture should be ruled out with MRI/MRCP and the stricture managed with ERCP if detected.

The new onset or worsening of itch may indicate benign or malignant biliary obstruction.

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