Treatment of Primary Sclerosing Cholangitis in Osteopenia (Bone Mineral Density T-score −2.5 to −1)
This protocol applies to patients with primary sclerosing cholangitis (PSC) who have osteopenia — a bone mineral density T-score between −2.5 and −1 — with a normal serum vitamin D level.
Clinical scenario
Patients with PSC can develop reduced bone mineral density. Osteopenia, characterised by a BMD T-score of −2.5 to −1, represents an intermediate stage of bone loss. This protocol is indicated when serum vitamin D remains within the normal range.
Approach (partial overview)
Management in this setting centres on supplementation to support bone mineral preservation. The complete agent selection and full regimen details are in the structured protocol →
References
- Osteopenia: Characterized by bone mineral density T-score standard deviation of −2.5 to −1.
- In patients with PSC with normal serum vitamin D levels who have osteopenia or osteoporosis, vitamin D (2000 IU/day) and calcium (1–1.5 g/day) supplementation should be administered.
DOI: 10.1002/hep.32771
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