Patients with primary sclerosing cholangitis (PSC) are at risk of developing bacterial cholangitis, a complication that requires prompt and targeted management. Addressing bacterial cholangitis in this context involves both immediate treatment and consideration of the underlying biliary disease.
Antibiotic therapy is central to managing bacterial cholangitis in the setting of PSC. Biliary imaging may be considered to assess ductal anatomy. In a subset of patients, longer-term preventive antibiotic strategies may be relevant. The complete protocol — including sequencing, specific considerations, and decision criteria — is available in full below.
Specific agents, dosing, duration, and full clinical algorithm are in the structured protocol.
DOI: 10.1002/hep.32771
Bacterial cholangitis should be treated with antibiotics; in rare cases, patients need to be on rotating antibiotics to prevent recurrent episodes.
Antibiotics should be used for bacterial cholangitis with consideration for MRCP to rule out relevant strictures.
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