In patients with primary Raynaud's phenomenon who continue to experience frequent vasospastic attacks despite consistent non-pharmacological management, the established next step is a structured pharmacological protocol aimed at reducing attack frequency.
Conservative first-line management — including cold avoidance, warm clothing (warm gloves and socks), smoking cessation, and patient education — did not achieve a meaningful reduction in the frequency of Raynaud's phenomenon attacks. Escalation to the next treatment line is indicated.
The protocol involves a pharmacological agent from a well-studied drug class. The approach typically begins at a low dose with gradual dose adjustment as tolerated. The complete regimen — including agent selection and dosing guidance — is available via the structured protocol below.
Reduction in the frequency of Raynaud's phenomenon attacks.
DOI: 10.1177/1759720X17740074