Treatment of Primary Ovarian Lymphoma in Gastric Extranodal Marginal Zone Lymphoma
Clinical Scenario
This protocol addresses primary ovarian lymphoma in patients presenting with gastric extranodal marginal zone lymphoma (gastric EMZL) — a distinct clinical setting that shapes the treatment approach from the outset.
Gastric EMZL context: The presence of gastric extranodal marginal zone lymphoma identifies a specific patient population for whom the underlying aetiology directly informs the first-line management strategy.
Treatment Approach (Partial Overview)
Management in this setting involves a targeted eradication strategy directed at an established infectious driver of gastric EMZL — given to all eligible patients as the standard initial step.
The complete regimen, sequencing, and management of non-response are detailed in the full structured protocol →
References
- Helicobacter pylori (H. pylori) eradication treatment should be given to all patients with gastric EMZL [II, A].
- In case of H. pylori persistence, alternative antibiotics and a proton pump inhibitor can be recommended [II, B].
DOI: 10.1016/j.annonc.2025.07.014
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