Treatment of Primary Ovarian Lymphoma with Diffuse Large B-Cell Histology in Patients Aged 80 Years or Older
Primary ovarian lymphoma with diffuse large B-cell lymphoma (DLBCL) histology in patients aged 80 or older requires a first-line approach that specifically accounts for the demands of advanced age. Standard regimens used in younger patients are not directly applicable in this population.
Clinical Scenario
This protocol is specific to patients with primary ovarian lymphoma of diffuse large B-cell histology who are aged 80 years or older. Age is a critical determinant of regimen selection in DLBCL and drives distinct treatment recommendations in this group compared with patients under 80.
Treatment Approach
First-line management centres on a chemoimmunotherapy regimen adapted in intensity for patients aged 80 or older, with a separate provision for the subset who are exceptionally fit. The complete regimen details, eligibility criteria, and individual assessment guidance are in the full protocol.
References
DOI: 10.1016/j.annonc.2025.07.014
Patients ≥80 years should receive six cycles of R plus reduced-dose CHOP (R-miniCHOP) [III, B].
Full-dose R-CHOP can be considered in extremely fit patients ≥80 years on a case-by-case basis [IV, C].
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