This protocol covers primary lymphoma of bone in the specific presentation of anaplastic large cell lymphoma (ALCL) with isolated skin disease in patients younger than 18 years at diagnosis.
The patient is a pediatric individual (under 18) diagnosed with anaplastic large cell lymphoma in which disease involvement is confined to the skin — isolated skin disease. Thorough staging to confirm the isolated nature of the presentation is a key step before any management decision.
For this specific presentation — ALCL with isolated skin disease in a patient under 18 — the structured evidence-based pathway following staging is defined. The complete sequencing and monitoring framework, including all relevant criteria, is available in the full protocol below.