Treatment of Primary Lymphoma of Bone in Anaplastic Large Cell Lymphoma — Completely Resected Stage I in Pediatric Patients

Clinical Scenario

This protocol covers primary lymphoma of bone presenting as anaplastic large cell lymphoma (ALCL) that has been completely resected at stage I, in patients younger than 18 years at diagnosis. Both criteria — confirmed ALCL histology with complete surgical resection at stage I, and pediatric age — define eligibility for this first-line approach.

Why This Situation Is Distinct

Completely resected stage I ALCL in a pediatric patient represents a localised, surgically controlled disease. This specific combination of histological subtype, disease extent, resection status, and age bracket drives a tailored chemotherapy strategy rather than a general non-Hodgkin lymphoma approach.

Treatment Approach (Partial Overview)

The regimen begins with an initial prephase step, followed by a structured sequence of chemotherapy courses. The full composition of each phase — including agents, scheduling, and supportive measures — is set out in the complete protocol.

Instant Access to Structured Evidence-Based Regimens

References

Stage I ALCL: completely resected stage I: prephase (V) + AM - BM - AM courses

<18 years old at diagnosis.

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