Gastric MALT Lymphoma Without H. pylori: When Antibiotic Therapy Does Not Achieve Remission
This protocol addresses gastric MALT-type lymphoma in patients without Helicobacter pylori infection. Almost 10% of MALT lymphomas are unrelated to H. pylori, and the pathogenesis in this subgroup remains unclear.
Antibiotic therapy was administered as the initial approach. However, remission of the gastric MALT lymphoma was not achieved — responses are typically expected between 3 and 9 months. Failure to reach remission is the trigger for escalation to this next treatment step.
The structured protocol for this situation centres on a targeted form of radiation therapy directed at the involved field. The complete regimen parameters are defined in the full protocol.
References
Almost 10% of MALT lymphomas are unrelated to H pylori infection, and the pathogenesis remains unclear.
Therefore, "involved-field" irradiation (total dose of 30 Gy administered over 4 weeks) has continued to be the preferred treatment for patients with stage I and stage II MALT lymphomas without H pylori or with persistent lymphomas following antibiotic therapy.
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