Primary gastric lymphoma (PGL) most commonly presents as gastric diffuse large B-cell lymphoma (DLBCL) — the predominant high-grade histological type in this setting. This protocol addresses first-line management of this specific presentation.
This protocol applies to patients with primary gastric lymphoma in the specific context of gastric diffuse large B-cell lymphoma — the most common histological type of gastric lymphoma, also referred to as high-grade gastric lymphoma.
The treatment of DLBCL-type primary gastric lymphoma centres on anthracycline-based chemoimmunotherapy. The complete structured regimen — including specific agents, sequencing, and alternative options for eligible patients — is detailed in the full protocol.
The primary clinical objective is complete remission of the gastric diffuse large B-cell lymphoma, assessed by PET CT at the end of therapy.