This protocol addresses primary cutaneous marginal zone lymphoma presenting as localized disease confined to the skin — a presentation where the extent of involvement directly determines the treatment strategy.
In this localized setting, management is built around local treatment strategies. Radiation-based approaches represent a well-established first-line option, with additional interventions considered depending on individual case factors. The complete regimen — including all modalities, selection criteria, and the full evidence-based algorithm — is available in the structured protocol below.
Complete response of the cutaneous lymphoma.
DOI: 10.3390/cancers12061497
In localized disease, first-line therapies are usually local radiation or surgical excision.
Complete response (CR) rate is close to 100% with local radiation, although relapses and acute adverse events (AE) occur in almost half of the cases.
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