Treatment of Primary Cutaneous ALCL Presenting with Solitary or Localised Tumours
This protocol addresses primary cutaneous anaplastic large cell lymphoma (C-ALCL) in patients who present with solitary or localised skin tumours or nodules, including ulcerating lesions — a distinct and clinically important presentation.
Clinical Scenario
Patients present with solitary or localised, sometimes ulcerating, tumours or nodules on the skin consistent with C-ALCL. Accurate recognition of this presentation pattern informs the treatment pathway.
Treatment Approach — Partial Overview
The protocol includes brentuximab vedotin as a component of management. Full treatment criteria, sequencing, and complete regimen details are available in the structured protocol below.
References
Patients with C-ALCL generally present with solitary or localised (ulcerating) tumours or nodules and should be treated with RT or surgical excision (Figure 2).
BV should be considered in cases with multifocal skin lesions refractory to conventional therapies and in patients developing extracutaneous disease [II, B].
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