Primary cutaneous anaplastic large cell lymphoma
ICD-10 C86.6 ICD-11 2B03.0&XH3400

Treatment of Primary Cutaneous ALCL Presenting with Solitary or Localised Tumours

This protocol addresses primary cutaneous anaplastic large cell lymphoma (C-ALCL) in patients who present with solitary or localised skin lesions, which may be ulcerating tumours or nodules — a common and well-defined clinical presentation.

Clinical Scenario
Patients with C-ALCL typically present with solitary or localised (ulcerating) tumours or nodules. This localised pattern defines the appropriate treatment approach for this first-line protocol.
Treatment Approach
For this presentation, local treatment directed at the involved skin site is the recommended first-line approach — either a locoregional physical modality or surgical removal of the lesion. Full regimen details, dosimetry guidance, and margin specifications are in the complete protocol ↓
Instant Access to Structured Evidence-Based Regimens

References

  1. Patients with C-ALCL generally present with solitary or localised (ulcerating) tumours or nodules and should be treated with RT or surgical excision (Figure 2).
  2. The ILROG suggests radiation with electrons, with bolus, a margin of 2 cm and a total dose of 24–30 Gy.
  3. In a recent study in 63 patients with C-ALCL, a total dose of 20 Gy in 8–10 fractions was found to be effective and well-tolerated in patients presenting with solitary or localised skin lesions.
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