This protocol addresses relapsed primary CNS lymphoma in patients whose disease returns late — after a prolonged remission achieved with a prior HD-MTX-based combination regimen. The duration of that initial remission is a key clinical factor in selecting the appropriate treatment strategy.
Relapsed primary CNS lymphoma with late relapse occurring after long-lasting remission following a previous HD-MTX-based combination. This pattern of late relapse distinguishes this group from patients with early or refractory disease.
The approach for this setting involves rechallenge with a chemotherapy regimen similar to the one used in first-line treatment. The full protocol — including patient selection criteria, the complete sequence, and consolidation considerations — is available in the structured regimen below.
Achievement of response — complete remission or partial response — confirmed on brain MRI.
DOI: 10.1016/j.annonc.2023.11.010