Primary central nervous system lymphoma
ICD-10 C83.8 · ICD-11 2A81.5

Treatment of relapsed or refractory primary CNS lymphoma when the patient is unfit for salvage polychemotherapy

Clinical scenario

This protocol addresses patients with primary central nervous system lymphoma who experience refractory disease or early relapse and are not candidates for salvage polychemotherapy. The limited tolerability of intensive re-induction regimens in this group requires an alternative treatment approach.

Treatment approach (partial overview)

Options in this setting include radiotherapy directed at the brain or monotherapy with a selected single agent. The structured protocol details the specific agents, their indications, and how to choose among them.

Full regimen details, sequencing, and selection criteria are available in the complete protocol.
Instant Access to Structured Evidence-Based Regimens

References

DOI: 10.1016/j.annonc.2023.11.010

Patients with refractory or early relapsed PCNSL unfit for salvage polyChT could be treated with WBRT or with a single drug such as ibrutinib, lenalidomide or temozolomide.

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