This protocol addresses the rare situation in which primary breast lymphoma takes the form of primary cutaneous anaplastic large cell lymphoma (pcALCL) — an indolent, ALK-negative subtype of ALCL that most commonly arises as localised skin nodules. When pcALCL presents as a primary breast lesion (PB-pcALCL), the clinical picture is uncommon and the published experience limited to isolated case reports.
pcALCL is considered a more indolent form of ALCL, typically ALK-negative, and usually presents as single or multiple localised skin nodules. Primary breast involvement (PB-pcALCL) is rarely reported. The described presentations include isolated breast lesions, sometimes accompanied by overlying skin changes, with the diagnosis confirmed histologically.
For this early-stage, localised presentation, the treatment approach involves a surgical intervention. The complete structured regimen — including the full sequence of management steps and follow-up strategy — is available in the protocol.