Treatment of Primary Breast Lymphoma in Extra-Nodal Marginal Zone Lymphoma
Primary breast extra-nodal marginal zone lymphoma (PB-MZL) is a distinct subtype of primary breast lymphoma. Its characteristically indolent clinical behaviour sets it apart and directly shapes the treatment strategy.
Clinical Scenario
Primary breast extra-nodal marginal zone lymphoma (PB-MZL) carries a similar incidence and prognosis to primary breast follicular lymphoma, but follows a more indolent course. This indolence is the central consideration when selecting a management approach.
Treatment Approach
Because of its indolent nature, PB-MZL is typically managed with a conservative, localised strategy — the full protocol specifies the options, clinical criteria, and additional considerations that determine which path is appropriate for a given patient.
References
Primary breast extra-nodal marginal zone lymphoma (PB-MZL) has a similar incidence and prognosis to PB-FL but is more indolent.
Owing to its indolent nature, most of the PB-MZL can be treated by lumpectomy or localised radiation therapy.
In some cases, women may opt for active surveillance.
DOI: 10.1016/j.jpra.2022.01.004
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