Primary biliary cholangitis
ICD-10 K74.3 · ICD-11 DB96.1

First-Line Treatment of Primary Biliary Cholangitis

Primary biliary cholangitis (PBC) is a chronic cholestatic liver disease requiring structured, evidence-based first-line pharmacological management to slow progression and preserve hepatic function.

Treatment Approach

First-line therapy for PBC centres on a bile acid agent — ursodeoxycholic acid. The complete dosing schedule, monitoring parameters, and response criteria are detailed in the full protocol.

Full regimen available in the structured protocol below.
Instant Access to Structured Evidence-Based Regimens

References

DOI: 10.1002/hep.32117

Fibrates can be considered as off-label alternatives for patients with PBC and inadequate response to ursodeoxycholic acid, although fibrates are discouraged in patients with decompensated liver disease.

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