Treatment of Postmenopausal Vaginal Bleeding with Mild Atrophic Endometritis

Postmenopausal vaginal bleeding arises from several distinct causes. When the finding is mild atrophic endometritis, the clinical approach differs from other aetiologies and warrants a specific, structured regimen.

Clinical scenario: Postmenopausal vaginal bleeding in the setting of mild atrophic endometritis. Atrophic endometritis is one of the recognised causes of postmenopausal bleeding, alongside endometrial and cervical polyps, endometrial hyperplasia, exogenous estrogens, and atrophic vaginitis.

Management approach: Mild atrophic endometritis in this setting can be managed with a targeted topical approach. The full selection criteria, regimen details, and follow-up plan are set out in the complete protocol below.

References

  • Other causes of PMB include endometrial/cervical polyps, endometrial hyperplasia, exogenous estrogens, atrophic endometritis and vaginitis (Figure 5).
  • Mild cases can be managed with long-term topical oestrogen.

DOI: 10.1016/j.ogrm.2025.09.009

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