Clinical Scenario

Ocular toxoplasmosis is the most common infective cause of posterior uveitis in immunocompetent patients. This protocol applies when the patient has no sulfa allergy, making the full range of first-line antiparasitic options available.

Treatment Approach — Partial Overview

First-line management centres on a combination antiparasitic regimen, with systemic corticosteroids introduced only after anti-infective therapy is established and folic acid supplementation maintained throughout. Several evidence-based alternative single-agent regimens are also defined for this setting — the complete sequenced protocol is available via the link below.

References

DOI: 10.4103/0301-4738.58470

Ocular toxoplasmosis is the most common infective cause of posterior uveitis in immunocompetent patients.
Treatment regimen consisting of a sulfonamide and a non-sulfonamide with systemic steroids and folic acid supplements is preferred.
In case of infective uveitis, systemic steroids need to be initiated at least 48–72 h after start of specific anti-infective therapy and then stopped at least 1 week prior to stoppage of specific treatment.

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Ocular Toxoplasmosis Causing Posterior Uveitis in an Immunocompetent Patient Without Sulfa Allergy

References