Non-Infective Posterior Uveitis: Treatment When Infective Causes Have Been Ruled Out

This protocol addresses posterior uveitis confirmed to be non-infective — a scenario that requires a different management approach once infectious aetiology has been systematically excluded.

Clinical Scenario

The patient presents with posterior uveitis in which infective causes have been thoroughly evaluated and excluded. Establishing this distinction is essential, as it directly determines the appropriate treatment pathway. Systemic steroids are the mainstay of therapy in non-infective posterior uveitis.

Treatment Approach (Overview)

For cases that prove refractory or develop associated complications, the structured protocol incorporates biological agents as well as targeted local drug delivery strategies — each matched to the specific complication pattern observed.

The complete evidence-based regimen, including step-by-step sequencing and the full range of therapeutic options, is available in the structured protocol below.