Penile Carcinoma in Situ (PeIN): Surgical Treatment When Topical Management Is Not Sufficient

For PeIN and T1a lesions where surgical management is indicated — including situations where topical treatment has not been adequate — a structured, evidence-based surgical protocol guides the appropriate intervention.

Treatment Approach

Management involves a surgical procedure targeting the affected tissue, with careful attention to both oncological control and preservation of form and function. The specific technique and its indications vary by lesion characteristics — the complete protocol details the procedural options and decision criteria.

Partial overview — full regimen available below

Instant Access to Structured Evidence-Based Regimens

References

If topical treatment fails, wide local excision or glans resurfacing, whereby the mucosal layer is removed and replaced with a split-thickness skin graft (SSG), should be considered.
Glans resurfacing is recommended for PeIN or T1a lesions with excellent oncological outcomes as well as aesthetic and functional outcomes.

DOI: 10.1016/j.esmoop.2024.103481 View source ↗