Treatment options for penile carcinoma in situ (PeIN)

Penile carcinoma in situ — also known as penile intraepithelial neoplasia (PeIN) — is non-invasive squamous neoplasia confined to the penile epithelium. Treatment selection depends on the extent and location of residual disease, and structured first-line protocols exist to guide management.

Treatment approach

For residual PeIN, the protocol covers the use of either a topical agent or an ablative procedural option — with specific selection criteria and conditions outlined in the full regimen.

Instant Access to Structured Evidence-Based Regimens

References

Following circumcision, any residual PeIN can be treated using topical agents, such as 5-fluorouracil (5-FU) or imiquimod.
Alternatively, carbon dioxide (CO2) laser ablation (penetration is 2-2.5 mm) can be used.

DOI: 10.1016/j.esmoop.2024.103481

View source ↗