Initial surgical management of biopsy-proven penile intraepithelial neoplasia (PeIN) on the glans or prepuce
Penile carcinoma in situ — also referred to as penile intraepithelial neoplasia (PeIN) — represents a pre-invasive lesion of the penis. When biopsy confirmation is obtained and the lesion involves the glans or prepuce, a specific initial surgical approach is indicated before any additional management is considered.
Clinical scenario
Biopsy-proven PeIN with involvement of the glans or prepuce — the anatomical location of the lesion is central to selecting the first management step in this protocol.
Approach overview
The initial management in this setting involves a targeted surgical intervention directed at the involved anatomical site. Full regimen details — including indications, sequence, and follow-up considerations — are in the complete protocol.
Complete protocol available via the link below.
References
DOI: 10.1016/j.esmoop.2024.103481
In cases of biopsy-proven PeIN located on the glans or prepuce, circumcision is mandatory as the initial management.
Circumcision is recommended as the initial treatment in any biopsy-proven PeIN located on the glans or prepuce.
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