This protocol applies to patients with invasive penile squamous cell carcinoma staged at T1 or T2, where disease is confined to the glans and prepuce. In this anatomically limited presentation, the primary clinical consideration is whether tissue-sparing approaches can be applied while ensuring adequate oncological control.
For lesions confined to the glans and prepuce — including PeIN, Ta, T1, and T2 — organ-sparing surgery combined with reconstructive techniques is the preferred approach when patients are willing to adhere to strict follow-up. The suitability of this strategy depends on tumour characteristics and the extent of local involvement.
When recurrence occurs, a surgical approach aimed at preserving organ structure may be considered in carefully selected cases — provided certain anatomical criteria are met. The full protocol specifies the decision criteria, procedural details, and follow-up requirements.