Treatment of Penile Cancer in Penile Intraepithelial Neoplasia (PeIN) or Non-Invasive Verrucous Carcinoma (Ta Stage)
This protocol addresses the management of early-stage, superficial penile cancer — specifically penile intraepithelial neoplasia (PeIN) or non-invasive verrucous carcinoma at the Ta stage. These lesions are confined to the epithelium and represent an important clinical decision point where organ-sparing surgical options are available.
Clinical scenario
The patient presents with superficial non-invasive penile disease: penile intraepithelial neoplasia (PeIN) or Ta-stage verrucous carcinoma. This category includes cases with extensive PeIN, residual disease at resection margins following prior ablative or topical therapy, or recurrent superficial disease.
Treatment approach
Surgical excision with glans resurfacing is the recommended approach for this stage — full details of the technique, reconstruction method, and clinical decision pathway are available in the complete protocol.
Complete regimen, sequencing, and technical specifics available via the structured protocol below.
References
- Treatment of superficial non-invasive disease (PeIN, Ta)
- Extensive PeIN – residual PeIN in resection margins or recurrent disease after ablative or topical therapy – can be treated by surgical excision.
- Glans resurfacing consists of full thickness removal of the glandular epithelium, followed by reconstruction with a graft (split skin or buccal mucosa for urethral reconstruction).
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