This protocol covers biopsy-confirmed penile intraepithelial neoplasia (PeIN) and non-invasive verrucous carcinoma at the Ta stage — a superficial, localised presentation of penile cancer where organ-preserving management is the priority.
The patient has superficial non-invasive penile disease: penile intraepithelial neoplasia (PeIN) or non-invasive verrucous carcinoma (Ta stage), confirmed on biopsy. These early-stage lesions do not invade the stroma and are amenable to local treatment strategies that preserve anatomy and function.
First-line options for this stage include non-invasive topical therapies, among other organ-preserving modalities. The full protocol details the available approaches, selection considerations, and the structured management algorithm — see the complete regimen below.