When locally advanced penile squamous cell carcinoma is not amenable to surgical resection, the management strategy shifts to non-operative approaches. Evidence-based guidance addresses this specific clinical situation.
Locally advanced penile squamous cell carcinoma that is not surgically resectable. For non-resectable advanced primary lesions — and for patients with locally advanced disease who decline surgical management — guidelines recommend systemic and radiation-based alternatives to surgery.
The evidence-based approach for this scenario centres on chemoradiotherapy incorporating integrated boost intensity-modulated radiotherapy delivered concurrently with systemic chemotherapy. One recognised advantage of this strategy over perioperative chemotherapy approaches is the potential to avoid surgery altogether.
Full regimen details — specific agents, dosing, fractionation schedule, and sequencing — are available in the complete structured protocol.