Patent Foramen Ovale Without Cryptogenic Stroke or Systemic Thromboembolism: What Does the Protocol Recommend?

Clinical Scenario

This protocol applies to patients with a known patent foramen ovale (PFO) who have no history of cryptogenic stroke and no systemic thromboembolism.

This presentation is distinct from PFO found in the context of unexplained stroke or embolic events, and the evidence-based approach differs accordingly.

Clinical Context

When a PFO is identified in the absence of cryptogenic stroke or systemic thromboembolism, the clinical significance of the finding is the central question. The protocol addresses how this scenario should be classified and managed based on current evidence.

The structured protocol below defines the recommended position on evaluation and management for this specific patient profile.

Instant Access to Structured Evidence-Based Regimens

References

Patients with a PFO and without CS should be reassured that no further exams are necessary.
As a consequence, in the absence of systemic thromboembolism, a PFO should be considered an anatomical variant instead of a pathologic condition.
Patients with known PFO should be reassured that neither exams nor interventions are required.

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