This protocol applies to patients with parotid gland (salivary gland) cancer who have recurrent locoregional disease that remains technically resectable, occurring in the context of distant metastatic disease that is not rapidly progressive or imminently lethal.
The defining features of this clinical situation are: resectable, recurrent locoregional salivary gland cancer, and concurrent distant metastatic disease. Eligibility for this approach depends critically on the character of the distant disease — it must be neither rapidly progressive nor imminently lethal. This distinction drives the treatment decision.
When these criteria are satisfied, a palliative surgical strategy directed at the locoregional disease — including resection and appropriate reconstruction — may be undertaken to preserve or improve quality of life. The full protocol details the scope of surgery, reconstruction considerations, and rehabilitation planning.
DOI: 10.1200/JCO.21.00449
In the setting of resectable, recurrent locoregional disease and distant metastatic disease, regardless of prior treatment type, treatment may include palliative revision resection and appropriate surgical reconstruction and rehabilitation, if the metastatic disease is not rapidly progressive or imminently lethal.
If the locoregional disease is technically resectable and with acceptable attendant morbidity, comprehensive surgical resection and reconstruction of locoregional disease can be undertaken to improve or preserve quality of life in the context of metastatic disease, which may not be lethal for years.
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