Treatment of Parkinson's Disease with Psychotic Symptoms and No Cognitive Impairment
Clinical scenario
This protocol addresses Parkinson's disease patients who develop psychotic symptoms in the absence of cognitive impairment. The co-occurrence of psychosis in Parkinson's disease requires a carefully considered management approach, as standard anti-psychotic options may not all be appropriate in this population.
Treatment approach (partial)
When psychotic symptoms arise in Parkinson's disease without cognitive impairment, specific anti-psychotic medication is considered — selected only after a thorough risk-benefit assessment accounting for the patient's overall profile.
The full regimen, including agent selection criteria and the role of cognitive status in guiding treatment choice, is available in the complete protocol below.
References
DOI: 10.1186/s42466-024-00325-4
- If these measures fail, specific anti-psychotic medication such as clozapine should be offered after appropriate risk–benefit assessment (risk of agranulocytosis, risk of myocarditis, risk of falls, anticholinergic side effects).
- Alternatively, quetiapine can be offered off-label in PD patients without cognitive impairment.
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