Treatment of Parkinson's Disease in Depression

In patients with Parkinson's disease, depression is a clinically significant non-motor comorbidity that warrants dedicated, targeted management.

Clinical scenario: Parkinson's disease with concurrent depression — a sub-population in which non-motor symptom control is a central treatment priority.

First-line management combines non-pharmacological approaches — including cognitive-behavioural and physical therapies — with pharmacological optimisation; the specific medication pathway depends on individual patient suitability and is detailed in the full protocol.

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References

Cognitive behavioral therapy is recommended to treat depression, anxiety, and fear of disease progression.
Physical interventions are recommended to treat depression, fatigue, and apathy.
Regarding pharmacotherapy, to treat depressive disorders in PD patients, optimal dopaminergic medication should be used and a therapy with Pramipexole should be conducted if therapy with a Dopamine agonist is possible.
Rotigotine can be used as a second-line option.

DOI: 10.1186/s42466-024-00325-4 View source ↗