Treatment of Pancoast Tumor: Trimodal Therapy Approach

Clinical Overview

Pancoast tumor requires a structured, sequenced treatment strategy. The evidence-based approach coordinates induction therapy, radical surgical resection, and further treatment after surgery — each step aimed at maximising response before and after the operative intervention.

Treatment Approach (partial overview)

The current standard of care is trimodal therapy: an induction phase combining concurrent chemoradiotherapy, followed by radical surgical resection. The complete protocol specifies the full induction regimen, the timing and scope of surgery, post-operative steps, and an alternative induction approach that incorporates immunotherapy — none of which are detailed here.

Clinical Goals

Treatment aims for a complete pathological response and downstaging of the lung tumor's TNM stage.

Instant Access to Structured Evidence-Based Regimens

References

DOI: 10.21037/ccts-24-29

The current standard treatment for Pancoast tumors has come to include the combination of induction chemoradiotherapy followed by radical surgical resection.
The standard of care is typically trimodal therapy, which includes induction chemoradiotherapy followed by surgery, with the ultimate goal of achieving a complete pathologic response and R0 resection.
A partial response was seen, with the tumor decreasing in size by 71%, and the TNM stage was downgraded to IA2.

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